光架橋性コム多糖を用いる新しい癒着防止技術の開発

DOI 被引用文献1件
  • 三輪 裕通
    国立循環器病センター生体工学部 信州大学第2外科
  • 松田 武久
    国立循環器病センター生体工学部
  • MOGHADDAM MJ
    Department of Biomedical Engineering, National Cardiovascular Center Research Institute

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タイトル別名
  • Development of new tissue adhesion prevention technology based on photocurable mucopolysaccharides.

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抄録

We are developing the tissue adhesion prevention technology based on photocurable mucopolysaccharides. Mucopolysaccharides were partially derivatized with photoreactive groups to attain photocurability. Ultraviolet irradiation produced water insoluble gels via intermolecular photodimerization of photoreactive groups. Photocured films with lower degrees of substitution (DSs) exhibited the high water swellability, whereas higher DS resulted in reduced swellability. Little cellular adhesion was observed on photocured films with low DSs. In vivo experiments, photocured film exhibited the tissue adhesion preventionability as well as biodegradability. As a photocurable mucopolysaccharide solution was coated on tissues, a viscous solution was converted to hydrogel by UV-irradiation. The in situ gelation of photocurable solution is expected to be useful in endoscopic surgery.

収録刊行物

  • 人工臓器

    人工臓器 22 (2), 376-379, 1993

    一般社団法人 日本人工臓器学会

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