定常流および拍動流完全右心バイパスの肺循環におよぼす影響に関する実験的研究及び臨床的検討

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タイトル別名
  • Effects of nonpulsatile and pulsatile right ventricular bypass on pulmonary circulation.

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The goal of this study is to clarify the effects of nonpulsatile perfusion on pulmonary circulation compared with pulsatile perfusion. Method: Right heart was totally (100%) bypassed between RA+RV and PA using a nonpulsatile (NP) or a pulsatile (P) blood pump in 14 dogs. The main PA was ligated, the bypass flow was maintained at the prebypass level throughout the experiment, and the systemic circulation was kept by natural beating heart. The parameters measured were such: extravascular lung water (EVLW), PAP, LAP, colloid osmotic pressure (COP), blood gas, cardiac output (CO), AoP, and CVP. Results: 1) A significant increase in EVLW was observed in the NP group after bypass (p<0.05). 2)Arterial PaO2 in the NP group had a tendency to be lower than the P group, although no statistical significance was observed. 3)No significant difference was observed between the NP and P groups on PAP, LAP, COP, and CO. The results suggest that nonpulsatile perfusion in pulmonary circulation has a higher tendency to accumulate lung water, although it does not differ significantly from pulsatile perfusion in gas exchange.

収録刊行物

  • 人工臓器

    人工臓器 19 (1), 190-195, 1990

    一般社団法人 日本人工臓器学会

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