コラーゲンスポンジを用いた新しい人工皮膚

DOI 被引用文献21件

書誌事項

タイトル別名
  • A new trilayer artificial skin composed of collagen matrix.

この論文をさがす

抄録

we have developed new trilayer artificial skin which is composed of the bottom layer of fibrillar collagen and heat-denatured collagen with the dehydrothermal crosslinking, and the central layer of fibrillar collagen with the chemical crosslinking, and the upper layer of a silicon elastmer. In this study, this artificial skin was “grafted” onto fullthickness skin defect of the rats' dorsal surface. 4 weeks after “grafting”, fibroblasts had infiltrated into the bottom layer, and the newly connective tissue composed of fold and wide collagen fiber, so called “pseudo-dermas”, had been formed. The epidermis accompanied with basement membrane migrated from the wound edge just as devided between bottom and central layer, and finally, rete ridge was formed. These results suggest that it is suitable to call it artificial skin proper.

収録刊行物

  • 人工臓器

    人工臓器 18 (1), 151-154, 1989

    一般社団法人 日本人工臓器学会

被引用文献 (21)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ