耳鼻いんこう科領域のけん気性菌感染症に対するＬｉｎｃｏｍｙｃｉｎの効果

• 栗山 一夫

  独協医科大学耳鼻咽喉科学教室

• 古内 一郎

  独協医科大学耳鼻咽喉科学教室

• 栗山 純一

  東京大学医学部附属病院分院耳鼻咽喉科学教室

書誌事項

タイトル別名

• Effect of Lincomycin on Anaerobic Bacterial Infections in Otolaryngological Patients

抄録

To evaluate the effects of lincomycin on anaerobic bacterial infections, lincomycin hydrochloride was administered to 20 outpatients (12 with acute pharyngitis, 2 with acute sinusitis, 1 with chronic sinusitis, 2 with chronic otitis media, 1 with acute otitis media, 1 with perichondritis auriculae and 1 with peritonsillar abscess).<br>The patients were given intramuscularly injections of 300-1200mg of lincomycin 1-2 times a day for 1 to 5 days.<br>Cultures yielded 22 bacterial strains (8 Peptococcus sp., 5 Peptostreptococcus sp., 5 Bacteroides fragilis, 3 Bacteroides melaninogenicus and 1 Fusobacterium sp.).<br>Minimal inhibitory concentrations (MIC) of lincomycin for anaerobes were determined by the agar dilution method.<br>Efficacy was determined by clinical improvement and eradication of bacteria at the time the drug was discontinued.<br>The overall efficacy rate was 73.7%.<br>Bacteria eradication rates were: Peptococcus sp. 83.3%, Peptostreptococcus sp. 60.0%, B. fragilis 100%, in 1 case both Peptococcus sp. and B, melaninogenicus, and in another both Peptococcus and B. fragilis were eradicated. Lincomycin was ineffective in a case of B. melaninogenicus and one of Fusobacterium sp. infection.<br>In this trial, the effectiveness of lincomycin against Peptostreptococcus sp. was 60.0% which is rather low compared with its usual high effectiveness against this strain reported elsewhere. This can be attributed to the fact that most of these patients had received other antibiotics possibly including macrolides such as erythromycin and oleandomycin which are known to induce cross resistance to lincomycin in other medical institutions before visiting us, and that may have produced induced resistance.

収録刊行物

• 耳鼻咽喉科臨床

  耳鼻咽喉科臨床 77 (9), 1871-1876, 1984

  耳鼻咽喉科臨床学会

キーワード

• Otorhinolaryngology

詳細情報

• CRID: 1390282679240299008
• NII論文ID: 130001809072
• DOI: 10.5631/jibirin.77.1871
• ISSN: 18844545
• ISSN: 00326313
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可