The Study of Epidermal Growth Factor in the Salivary Glands. The Kinetics of Epidermal Growth Factor in the Saliva of Normal Subjects and Patients with Oral Disease.
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- Ino Motoko
- Kansai Medical University
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- Ushiro Koichi
- Kansai Medical University
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- Ino Ghiyonori
- Kansai Medical University
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- Yamashita Toshio
- Kansai Medical University
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- Kumazawa Tadami
- Kansai Medical University
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- Takahashi Tohru
- Kansai Medical University
Bibliographic Information
- Other Title
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- 唾液腺の上皮成長因子(EGF)に関する研究 ヒト唾液中EGFの動態
- -The Kinetics of Epidermal Growth Factor in the Saliva of Normal Subjects and Patients with oral Disease-
- ―ヒト唾液中EGFの動態―
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Abstract
Human epidermal growth factor (hEGF) stimulates the growth and differentiation of various tissues. To study the kinetics of hEGF in saliva of normal subjects and patients with oral disease, we measured EGF levels in saliva (n=128), urine (n=94), and serum (n=99) using radioimmunoassay. Salivary EGF level showed apparent diurnal rhythm related to taking of meals. Urinary and serum EGF levels showed no obvious diurnal rhythm. There was no significant correlation between salivary and urinary EGF levels, or between salivary and serum EGF levels. Salivary EGF level in adults (10 to 79 years old) was not correlated with age, but it was significantly lower (3.06±0.32 ng/ml) in children (0 to 9 years old) than in adults. Urinary EGF level in children, however, was significantly higher than that in adults. Moreover, there was no significant difference between males and females in EGF level in saliva, urine, or serum. The relative proportions of EGF levels in the submaxillary gland saliva, parotid saliva, and whole saliva were 1: 6: 4. Salivary EGF level of patients with intraoral inflammation (stomatitis aphthosa or peritonsillitis) or intraoral tumor (cancer of the tongue, oral cavity, hypopharynx, or larynx) was markedly low. The pathophysiologic significance of this finding is worthy of study. Low salivary EGF level may reduce the capacity of the oral mucosal defense mechanisms against injury by physiochemical agents.
Journal
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- Practica Oto-Rhino-Laryngologica
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Practica Oto-Rhino-Laryngologica 84 (11), 1633-1640, 1991
The Society of Practical Otolaryngology
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Details 詳細情報について
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- CRID
- 1390282679238156928
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- NII Article ID
- 130001811826
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- ISSN
- 18844545
- 00326313
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed