舌か粒細胞腫例　起源細胞の免疫組織化学検討

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  • Immunohistochemical Study of Granular Cell Tumor of Tongue.
  • ―起源細胞の免疫組織化学的検討―

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The histogenesis of granular cell tumor is still controversial.<br>A 21-year-old woman complained of a tumor on the dorsum of her tongue. Since the tumor had no capsule, it was resected totally together with muscle tissue of the tongue.<br>The tumor cells were proliferated diffusely and arranged in small nests in H. E. stained sections. Axon-like dark brown fibrils were seen in the tumor nests in sections stained by the Bodian technique.<br>Immunohistochemical studies showed reactivity for S100 protein. On the other hand, neither NSE nor GFAP were detected in the tumor cells.<br>These findings suggest that this tumor is derived from Schwann cells of peripheral nerve fascicles.

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