ストレプトマイシン, トブラシン投与患者における頭位性めまいについて

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タイトル別名
  • Nystagmus Test in Patients Treated with Ototoxic Drugs
  • ストレプトマイシン トブラシン トウヨ カンジャ ニ オケル トウイセイメマイ

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抄録

Positional and positioning nystagmus tests were performed in 48 patients treated with either streptomycin sulfate (SM) or kanamycin (KM) and 17 patients treated with tobracin (TOB). Average pure tone thresholds of 4 frequencies (500, 1000, 2000 and 4000Hz) tended to be greater (24.1dB) in KM group than SM group (16.4dB). Nystagmus was observed in 8 out of 48 subjects (16.7%). Average SM dosage of the group with nystagmus was 23.2g which was not significantly different from that of non-nystagmus group. This probably indicates variable susceptibility of the vestibular system to SM among individuals. Overall pure tone threshold in non-nystagmus group was within normal range, whereas most of the pure tone thresholds in group with nystagmus ranged from 16 to 60dB. This indicates necessity of vestibular function test in the early stage as well as conventional hearing test in order to detect mild vestibular dysfunction. Types of nystagmus observed varied among subjects, such as horizontal, horizontal-rotatory and pure rotatory. Only 3 out of 8 patients with nystagmus were complaining of vertigo. Furthermore, vertigenous symptom was not related to characteristics of nystagmus. No nystagmus was observed in the KM and TOB treated patients.

収録刊行物

  • 耳鼻咽喉科臨床

    耳鼻咽喉科臨床 75 (11special), 2399-2403, 1982

    耳鼻咽喉科臨床学会

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