Nicotineのマウス肝に及ぼす影響の病理組織学的研究

• 石塚 信彦

  昭和医科大学病理学教室

書誌事項

タイトル別名

• HISTOPATHOLOGICAL STUDIES ON THE INFLUENCE OF NICOTINE ON THE LIVER OF MICE

抄録

In the present work, injection of aqueous solution of nicotine and solution of olive oil were given to mice subcutaneously to investigate histopathologically the toxicity of these solution on the liver.<BR>When injections of nicotine solution exceeding 3.0 mg were given, general clonic convulsion was observed, thus deaths were caused among the animals of 3.0 mg group, 5.0 mg group and 7.0 mg groups at the rate of 10%, 25% and 20% respetively. These rates were higher than that treated with olive oil. As the histopathological changes in the liver, swelling, granular degeneration, vacuolar degeneration and nuclear degeneration of the liver cells were observed. The degree of these pathological changes was found mild up to the dosis of 3.0 mg, but it was found strong when the dosis was raised to 5.0 mg or 7.0 mg in every instance.<BR>The vacuolar degeneration of the liver cells were observed not infrequently in combination with the granular degeneration. Only in the case with 3.0 mg nicotine oil solution, this change was noted at the rate of 48%, but in all other cases, the rate was 80-100% showing no parallelism with the increase in the dosis of nicotine.<BR>Both of the granular and vacuolar degenerations of liver cells observed in the present experiments were understood as the morphological indication to the organ due to tissue intoxication induced by nicotine, and the vacuolar degeneration was considered the morphological picture of the edematous changes due to the obstruction in the water metabolism of the tissue cells.<BR>The fact, that the accumulation of nicotine in the mice which were consecutively administered with nicotine was not so marked, was considered to be due to the fairly rapid excretion of nicotine by the mice, unlike the case of the formation of marked dermal edema of chick embryo, which posesses a specific excretory mechanism.<BR>Both of the granular and vacuolar degenerations of the liver cells was considered a tissue intoxication, secondarily induced intoxication, which is belonging to secondary direct type.

収録刊行物

• 昭和医学会雑誌

  昭和医学会雑誌 17 (1), 74-91, 1957

  昭和大学学士会

詳細情報

• CRID: 1390282679811899136
• NII論文ID: 130001820543
• DOI: 10.14930/jsma1939.17.74
• ISSN: 21850976
• ISSN: 00374342
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可