MATRIX METAOLLOPROTEINASE-9, SIALYL LEWISA, AND LAMININ IN COLORECTAL CANCER: RELATIONSHIP TO CLINICOPATHOLOGICAL FACTORS AND LIVER METASTASIS

• KATO Kenji

  Division of Gastroenterology, Showa University Fujigaoka Hospital

• HATTORI Takashi

  Division of Gastroenterology, Showa University Fujigaoka Hospital

• FUNATSU Yasuhiro

  Division of Gastroenterology, Showa University Fujigaoka Hospital

• ENDO Yutaka

  Division of Gastroenterology, Showa University Fujigaoka Hospital

• URAGAMI Naoyuki

  Division of Gastroenterology, Showa University Fujigaoka Hospital

• KARASAWA Takafumi

  Division of Gastroenterology, Showa University Fujigaoka Hospital

• FUJITA Rikiya

  Division of Gastroenterology, Showa University Fujigaoka Hospital

• OKA Hisashi

  Division of Surgery, Showa University, Fujigaoka Hospital

• FUKUCHI Kunihiko

  Division of Clinical Pathology, Showa University

Bibliographic Information

Other Title

• 大腸癌におけるMatrix Metalloproteinase-9, Sialyl LewisA, Lamininの発現と肝転移

Abstract

Using immunohistochemical staining, we have examined the expression of Matrix Metalloproteinase-9 (MMP-9), Sialyl LewisA (Sialyl Le^a), and Laminin in 49 colorectal cancers and analyzed the correlation of clinicopathological factors and liver metastasis. The positive rate of MMP-9 was significantly high (77%) in cases with liver metastasis (p=0.025) . Sialyl Le^a staining was 96% (47/49) positive in 49 cases. Stromal staining was 54% in cases of liver metastasis. Statistical analysis showed that the presence of a stromal staining pattern correlated with the development of venous invasion (p=0.017) . It was difficult to evaluate the liver metastasis and venous invasion by means of only Sialyl Le^a staining because of the abundance of the quasipositive rate. Laminin was positive only in 15% of cases with liver metastasis. In this study, the presence of MMP-9 in cancerous tissues might be a good marker of liver metastasis..

Journal

• Journal of The Showa Medical Association

  Journal of The Showa Medical Association 60 (6), 670-676, 2000

  The Showa University Society

Keywords

• colorectal cancer
• liver metastasis
• Matrix Metalloproteinase-9 (MMP-9)
• Sialyl LewisA (Sialyl Le<SUP>a</SUP>)
• Laminin

Details

• CRID: 1390001204835561728
• NII Article ID: 130001823226
• DOI: 10.14930/jsma1939.60.670
• COI: 1:CAS:528:DC%2BD3MXjtVKqtr8%3D
• ISSN: 21850976
• ISSN: 00374342
• Web Site: https://search.jamas.or.jp/link/ui/2001203120
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed