Acaricidal Activity of DHEMH, Derived from Patchouli Oil, against House Dust Mite, Dermatophagoides farinae
-
- Wu Hai-Qiang
- College of Life Sciences, Shenzhen University
-
- Li Li
- College of Life Sciences, Shenzhen University
-
- Li Jing
- College of Life Sciences, Shenzhen University
-
- He Zhen-Dan
- College of Medicine, Shenzhen University
-
- Liu Zhi-Gang
- College of Medicine, Shenzhen University
-
- Zeng Qing-Qian
- Guangdong Research Institute of Traditional Chinese Medicines
-
- Wang Yu-Sheng
- Guangdong Research Institute of Traditional Chinese Medicines
この論文をさがす
抄録
This study characterized the acaricidal activity of constituents of patchouli oil extracted from (Pogostemon cablin (Blanco) BENTH) against the house dust mite, Dermatophagoides farinae. A new compound, 2-(1,3-dihydroxy-but-2-enylidene)-6-methyl-3-oxo-heptanoic acid (DHEMH), was isolated from patchouli oil and characterized by 1H-NMR, 13C-NMR, LC-MS and elemental analysis (EA). This active component was identified as the hydrolysate of pogostone. Fifteen other constituents found in patchouli oil were also identified by GC-MS, including patchouli alcohol and pogostone. LD50 studies carried out over 24 h using contact toxicity tests identified DHEMH as the most toxic compound to D. farinae (2.04 μg/cm2), followed by patchouli oil (6.11 μg/cm2), benzyl benzoate (BP) (9.31 μg/cm2) and dibutyl phthalate (DBP) (58.52 μg/cm2). In vapor phase toxicity tests, all of these compounds were more effective in closed than open containers, indicating that the most efficient mode of delivery for these compounds is the vapor phase. These results indicate that DHEMH and patchouli oil merit further study as potential agents for the control of D. farinae.
収録刊行物
-
- CHEMICAL & PHARMACEUTICAL BULLETIN
-
CHEMICAL & PHARMACEUTICAL BULLETIN 60 (2), 178-182, 2012
公益社団法人 日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282679153937280
-
- NII論文ID
- 130001852394
-
- NII書誌ID
- AA00602100
-
- ISSN
- 13475223
- 00092363
-
- NDL書誌ID
- 023407320
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可