Synthesis of Novel Tetrahydro-1H-pyrazolo[4,3-c]pyridines via Intramolecular Nitrilimine Cycloaddition

• Garofalo Albert William

  Department of Medicinal Chemistry, Élan Pharmaceuticals

• Jagodzinski Jacek Jerzy

  Department of Process and Analytical Chemistry, Élan Pharmaceuticals

• Konradi Andrei William

  Department of Medicinal Chemistry, Élan Pharmaceuticals

• Ng Raymond Anthony

  Department of Medicinal Chemistry, Élan Pharmaceuticals

• Semko Christopher Michael

  Department of Medicinal Chemistry, Élan Pharmaceuticals

• Sham Hing Leung

  Department of Medicinal Chemistry, Élan Pharmaceuticals

• Sun Minghua

  Department of Medicinal Chemistry, Élan Pharmaceuticals

• Ye Xiaocong Michael

  Department of Medicinal Chemistry, Élan Pharmaceuticals

書誌事項

タイトル別名

• Synthesis of Novel Tetrahydro-1<i>H</i>-pyrazolo[4,3-<i>c</i>]pyridines <i>via</i> Intramolecular Nitrilimine Cycloaddition

抄録

The preparation of novel tetrahydro-1H-pyrazolo[4,3-c]pyridines is reported. Pivotal to the synthesis of these compounds was the development of mild reaction conditions to generate a highly functionalized nitrilimine capable of undergoing an intramolecular cycloaddition with a tethered alkyne. The desired cycloadduct was formed as an equal mixture of diastereomers.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 60 (8), 1063-1066, 2012

  公益社団法人 日本薬学会

キーワード

• intramolecular cycloaddition
• nitrilimine
• pyrazole
• γ-secretase inhibitor

詳細情報

• CRID: 1390282679153957376
• NII論文ID: 130001852504
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.c110498
• COI: 1:STN:280:DC%2BC38flsFWgtg%3D%3D
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 023834712
• PubMed: 22863711
• Web Site: http://id.ndl.go.jp/bib/023834712
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023834712
• Web Site: https://www.jstage.jst.go.jp/article/cpb/60/8/60_c110498/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可