Activation of Anterior Cingulate Cortex Extracellular Signal-Regulated Kinase-1 and -2 (ERK1/2) Regulates Acetic Acid-Induced, Pain-Related Anxiety in Adult Female Mice
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- Zhong Xiao-Lin
- Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University
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- Wei Rong
- Clinic Medicine of 8-year Program, Xiangya School of Medicine, Central South University
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- Zhou Pei
- Department of Anesthesia, The Second Xiangya Hospital of Central South University
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- Luo Yan-Wei
- Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University
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- Wang Xue-Qin
- Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University
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- Duan Juan
- Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University
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- Bi Fang-Fang
- Department of Neurology, Xiangya Hospital, Central South University
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- Zhang Jian-Yi
- Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University
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- Li Chang-Qi
- Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University
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- Dai Ru-Ping
- Department of Anesthesia, The Second Xiangya Hospital of Central South University
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- Li Fang
- Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University
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抄録
In visceral pain, anxiety and pain occur simultaneously, but the etiogenesis of this effect is not yet well-described. The anterior cingulate cortex (ACC) is known to be associated with the affective response to noxious stimuli. The aim of the current study is to define the role of ACC extracellular signal-regulated (ERK)-1 and-2 (ERK1/2) activity in the development of pain-related anxiety/depression and the nocifensive response in acetic acid (AA)-elicited visceral pain. The model of visceral pain was created by intraperitoneal (ip) injection of AA to female Kunming mice. We found that AA injection resulted in a dynamic, bilateral ERK1/2 activation pattern in the ACC. Inhibition of ERK1/2 activation 2 hr after AA injection by subcutaneous (sc) injection of the mitogen-activating extracellular kinase (MEK) inhibitor, SL327, had no effect on the nocifensive responses, but did attenuate anxiety-like behavior, as determined by elevated plus-maze and open-field testing results. These data suggest that AA-induced visceral pain activates expression of ACC ERK1/2, which regulates visceral pain-related anxiety, but not the nocifensive response.<br>
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- Ａｃｔａ Ｈｉｓｔｏｃｈｅｍｉｃａ ｅｔ Ｃｙｔｏｃｈｅｍｉｃａ
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Ａｃｔａ Ｈｉｓｔｏｃｈｅｍｉｃａ ｅｔ Ｃｙｔｏｃｈｅｍｉｃａ 45 (4), 219-225, 2012
日本組織細胞化学会