Combined Assessment of Baroreflex Sensitivity With Iodine 123 Metaiodobenzylguanidine Scintigraphic Findings Strengthens the Power of Predictive Value for Cerebral and Cardiovascular Events in Type 2 Diabetic Patients
-
- Murozono Yukichi
- Cardiovascular Science, Faculty of Medicine, Oita University
-
- Yufu Kunio
- Department of Laboratory Examination and Diagnostics, Oita University
-
- Takahashi Naohiko
- Department of Laboratory Examination and Diagnostics, Oita University
-
- Okada Norihiro
- Cardiovascular Science, Faculty of Medicine, Oita University
-
- Shinohara Tetsuji
- Cardiovascular Science, Faculty of Medicine, Oita University
-
- Nakagawa Mikiko
- Department of Laboratory Examination and Diagnostics, Oita University
-
- Hara Masahide
- Cardiovascular Science, Faculty of Medicine, Oita University
-
- Saikawa Tetsunori
- Department of Laboratory Examination and Diagnostics, Oita University
この論文をさがす
抄録
Background: We previously reported that baroreflex sensitivity (BRS) or cardiac iodine 123 metaiodobenzylguanidine (123I-MIBG) scintigraphic findings can predict cardiovascular prognosis in type 2 diabetic patients. We therefore tested the hypothesis that the combination of BRS and 123I-MIBG scintigraphic findings could strengthen the predictive power for major adverse cerebral and cardiovascular events (MACCE). Methods and Results: From 1998, we have evaluated both BRS and 123I-MIBG scintigraphy in 165 type 2 diabetic patients (77 females, 88 males, mean age 59±12 years). Based on the ROC curves, depressed BRS was defined as <5.63mmHg/s, and enhanced washout ratio (WR) was defined as ≥41.4%. Each patient was divided into 3 groups based on the “BRS-MIBG combination score” as follows: 0, patients having both preserved BRS and preserved WR; 1, patients having either depressed BRS or enhanced WR; 2, patients having both depressed BRS and enhanced WR. During the mean of 4.7±2.7 years of follow-up, 19 patients developed MACCE. The MACCE-free ratio was significantly higher in the lower BRS-MIBG combination score group (log-rank 16.41, P=0.0003). Cox proportional hazards regression analysis revealed that BRS-MIBG combination score was independently associated with the incidence of MACCE (hazard ratio 4.06, P=0.0237). Conclusions: Our results suggest that combined assessment of the BRS and 123I-MIBG scintigraphic findings is more useful for identifying the type 2 diabetic patients at high risk for MACCE. (Circ J 2013; 77: 130–136)<br>
収録刊行物
-
- Circulation Journal
-
Circulation Journal 77 (1), 130-136, 2013
一般社団法人 日本循環器学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282680080592512
-
- NII論文ID
- 10031131578
-
- NII書誌ID
- AA11591968
-
- COI
- 1:CAS:528:DC%2BC3sXhsVWnsLk%3D
-
- ISSN
- 13474820
- 13469843
-
- PubMed
- 23018680
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可