Hyponatremia as a Predictor for Worsening Heart Failure in Patients Receiving Cardiac Resynchronization Therapy

• Arao Kenshiro

  Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University

• Fujiwara Takayuki

  Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University

• Sakakura Kenichi

  Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University

• Wada Hiroshi

  Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University

• Sugawara Yoshitaka

  Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University

• Suga Chikashi

  Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University

• Ako Junya

  Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University

• Ishikawa San-e

  Division of Endocrinology, Saitama Medical Center, Jichi Medical University

• Momomura Shin-ichi

  Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University

抄録

Background: Various factors associated with worsening heart failure (HF) events have been investigated in HF subjects. The purpose of this study was to identify the predictive factor(s) for worsening HF events after cardiac resynchronization therapy (CRT) among baseline parameters, as well as baseline factors associated with responsiveness or non-responsiveness to CRT. Methods and Results: Seventy-seven HF patients with an indication for CRT were enrolled. Baseline parameters of blood chemistry, electrocardiogram, echocardiogram and cardiac catheterization before device implantation were measured, and subsequent clinical HF events after CRT were investigated. During the follow-up period (median 601 days), 22 of 77 (29%) recipients had HF events (unscheduled HF hospitalization: 16; use of left ventricular assist system: 1; heart transplantation: 1; cardiac death: 4). In the multivariate Cox proportional hazards model, low serum sodium concentration was associated with the occurrence of HF events after CRT (hazard ratio 0.82, 95% confidence interval 0.68–0.99, P=0.034). At baseline, serum sodium concentration negatively correlated with pulmonary capillary wedge pressure (r=−0.71, P<0.001) and with plasma arginine vasopressin level (r=−0.68, P=0.008). Conclusions: Hyponatremia is an independent predictor for worsening HF events after CRT implantation, which may be partly explained by elevated level of plasma arginine vasopressin.  (Circ J 2013; 77: 116–122)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 77 (1), 116-122, 2013

  一般社団法人 日本循環器学会

キーワード

• Cardiac resynchronization therapy
• Chronic heart failure
• Prognosis
• Sodium

詳細情報

• CRID: 1390282680080569216
• NII論文ID: 10031131576
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-12-0672
• ISSN: 13474820
• ISSN: 13469843
• PubMed: 23018767
• Web Site: https://www.jstage.jst.go.jp/article/circj/77/1/77_CJ-12-0672/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013357869
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可