書誌事項
- タイトル別名
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- Biological Functions of the Duplicated GGAA-motifs in Various Human Promoter Regions
- ヒト イデンシ プロモーター ニ ソンザイ スル チョウフク GGAA ハイレツ ノ セイブツガクテキ ヤクワリ
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Transcription is one of the most fundamental cellular functions and is an enzyme-complex mediated reaction that converts DNA sequences into mRNA. TATA-box is known to be an important motif for transcription. However, there are majority of promoters that have no TATA-box. They are called as TATA-less promoters and possess other elements that determine the transcription start site (TSS) of the genes. Multiple protein factors including ETS family proteins are known to recognize and bind to the GGAA containing sequences. In addition, it has been reported that the ETS binding motifs play important roles in regulation of various promoters. Here, we propose that the duplication and multiplication of the GGAA motifs are responsible for the initiation of transcription from TATA-less promoters.<br>
収録刊行物
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- 薬学雑誌
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薬学雑誌 131 (12), 1787-1800, 2011-12-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001206127856640
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- NII論文ID
- 130001871780
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 023353045
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可