有機カチオン輸送系を介した白金系抗がん剤の腎毒性発現機構

DOI Web Site Web Site PubMed 被引用文献1件 参考文献12件

書誌事項

タイトル別名
  • Platinum Agent-induced Nephrotoxicity <i>via</i> Organic Cation Transport System
  • ユウキ カチオン ユソウケイ オ カイシタ ハッキンケイ コウガンザイ ノ ジンドクセイ ハツゲン キコウ

この論文をさがす

抄録

  Platinum agents are widely used in cancer chemotherapy. Cisplatin, carboplatin, oxaliplatin and nedaplatin have a common chemical structure consisting of platinum, carrier groups and leaving groups, and undergo the similar mechanism of cytotoxicity. Only cisplatin induces nephrotoxicity, although the molecular mechanism involved is unclear. Organic cation transporter (OCT)/SLC22A, and multidrug and toxin extrusion (MATE)/SLC47A play a role in renal handling of cationic drug in the kidney. We focused on a role of transporters in nephrotoxicity of platinum agents. OCT2 mediates the transport of cisplatin and is the determinant of cisplatin-induced nephrotoxicity. In addition, MATE1 protects cisplatin-induced nephrotoxicity. Oxaliplatin, which was a superior substrate of the luminal efflux transporter, MATE2-K as well as OCT2, did not show nephrotoxicity. Moreover, carboplatin and nedaplatin were not transported by these transporters. Substrate specificity could regulate the features of platinum agents. Recent findings indicate that organic cation transporters are key to the nephrotoxicity of platinum agents.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 132 (11), 1281-1285, 2012-11-01

    公益社団法人 日本薬学会

被引用文献 (1)*注記

もっと見る

参考文献 (12)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ