書誌事項
- タイトル別名
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- Enhancement of Regulatory T Cell Induction by Intravenous S-sulfonated Immunoglobulin during the Treatment of Experimental Autoimmune Encephalomyelitis
- ジッケンテキ ジコ メンエキセイ ノウ セキズイエン ノ チリョウ ニ オケル ジョウチュウヨウ スルホカ メンエキ グロブリン ニ ヨル セイギョセイ T サイボウ ノ ユウドウ
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Intravenous immunoglobulin (IVIg) has been shown to be effective for a variety of autoimmune diseases. Despite its widespread use and therapeutic success, the precise mechanisms for the anti-inflammatory therapeutic effects of IVIg are not well understood. In particular, few reports have examined the mechanism of IVIg on regulatory T cells (Treg: CD4+CD25+FoxP3+ T cells). In the present study, to clarify the effect of intravenous S-sulfonated immunoglobulin (S-IVIg) on Treg, we investigated experimental autoimmune encephalomyelitis (EAE), the representative animal model of autoimmune disease. First, when we evaluated the effect of S-IVIg in an acute EAE model, the prophylactic treatment of S-IVIg dose-dependently controlled the symptoms of EAE. Next, we measured Treg in EAE mice spleen by flow cytometry. The percentage of Treg in S-IVIg-treated mice was significantly increased compared with Saline-treated mice. Finally, in reinduced EAE, S-IVIg not only prevented EAE progression, but also increased the percentage of Treg in the spleen. The increase in percentage of Treg in S-IVIg-treated EAE might be associated with protection against EAE. These observations provide important evidence that IVIg is effective in T-cell-mediated control of autoimmunity.<br>
収録刊行物
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- 薬学雑誌
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薬学雑誌 132 (2), 243-249, 2012-02-01
公益社団法人 日本薬学会
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詳細情報
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- CRID
- 1390001206127347328
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- NII論文ID
- 130001872016
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 023511193
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可