Tetomilast Attenuates Elastase-Induced Pulmonary Emphysema through Inhibition of Oxidative Stress in Rabbits

• Baila Bulin

  Second Department of Internal Medicine, Graduate School of Medicine, Gifu University

• Ohno Yasushi

  Second Department of Internal Medicine, Graduate School of Medicine, Gifu University

• Nagamoto Hisashi

  Otsuka Pharmaceutical Co., Ltd.

• Kotosai Kounori

  Otsuka Pharmaceutical Co., Ltd.

• Yabuuchi Youichi

  Otsuka Pharmaceutical Co., Ltd.

• Funaguchi Norihiko

  Second Department of Internal Medicine, Graduate School of Medicine, Gifu University

• Ito Fumitaka

  Second Department of Internal Medicine, Graduate School of Medicine, Gifu University

• Endo Junki

  Second Department of Internal Medicine, Graduate School of Medicine, Gifu University

• Mori Hidenori

  Second Department of Internal Medicine, Graduate School of Medicine, Gifu University

• Takemura Genzou

  Second Department of Internal Medicine, Graduate School of Medicine, Gifu University

• Fujiwara Takako

  Kyoto Womens University

• Fujiwara Hisayoshi

  Second Department of Internal Medicine, Graduate School of Medicine, Gifu University

• Minatoguchi Shinya

  Second Department of Internal Medicine, Graduate School of Medicine, Gifu University

抄録

Tetomilast was originally identified as a potent inhibitor of superoxide production in human neutrophils, and is of interest because it may relieve oxidative stress related to chronic obstructive pulmonary disease (COPD). Our objective was to determine whether tetomilast effectively protects against the development of porcine pancreatic elastase (PPE)-induced emphysema in rabbits. Rabbits were divided into three groups (sham n=19, PPE n=19, PPE/Tetomilast n=18). The rabbits were once daily orally administered vehicle solution or tetomilast 5 d/week for 4 weeks before the PPE instillation. We compared pulmonary function, inflammatory cell infiltration, oxidative stress, and the incidences of apoptosis among the three groups. Tetomilast suppressed PPE-induced increases in the incidence of apoptosis and the production of 8-hydroxy-deoxyguanosine (8-OHdG) in lung tissues. PPE-instilled rabbits treated with tetomilast showed significantly less mean linear intercept and significantly better pulmonary function than rabbits administered PPE alone. Tetomilast may inhibit the development of emphysema by attenuating pulmonary inflammation and apoptosis caused by PPE-induced oxidative stress.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 35 (4), 494-502, 2012

  公益社団法人 日本薬学会

キーワード

• chronic obstructive pulmonary disease
• tetomilast
• oxidative stress
• 8-hydroxy-deoxyguanosine

詳細情報

• CRID: 1390282679609206016
• NII論文ID: 130001872196
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.35.494
• COI: 1:STN:280:DC%2BC38rhtlGhsQ%3D%3D
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 023532889
• PubMed: 22466552
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023532889
• Web Site: https://www.jstage.jst.go.jp/article/bpb/35/4/35_4_494/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013012486
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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