Erythroid Recovery Affects Tacrolimus Levels after Engraftment during Stem Cell Transplantation
-
- Fukuoka Noriyasu
- Department of Pharmacy, Kagawa University Hospital
-
- Imataki Osamu
- Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University
-
- Tanaka Hiroaki
- Department of Pharmacy, Kagawa University Hospital
-
- Tani Kumiko
- Department of Pharmacy, Kagawa University Hospital
-
- Ohnishi Hiroaki
- Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University
-
- Houchi Hitoshi
- Department of Pharmacy, Kagawa University Hospital
この論文をさがす
抄録
Tacrolimus is commonly used in stem-cell transplants (SCT) for prophylaxis of graft-versus-host disease and is continuously administered throughout transplantation. The dose of tacrolimus is frequently decreased to maintain a desired concentration during the recovery of hemocytes after engraftment. If parameters which affect tacrolimus clearance are identified, it is of clinical use to estimate concentrations and aid dosing. The objective of this study was to identify which hematologic parameters affect tacrolimus clearance. Seventeen consecutive Japanese patients with hematological malignancies who received allogeneic SCT between March 2004 and January 2007 were enrolled in this study. Their steady-state concentrations were routinely measured and standardized as the concentration/dose (C/D) ratio ((ng/mL)/(mg/kg/d)). Multivariate analysis was performed to identify which hemocyte parameters affected the C/D ratio. Of the 13 patients, gradual dose reduction was required to combat elevated tacrolimus concentrations. The mean post-engraftment C/D ratio was higher than the pre-engraftment C/D ratio in each patient. The mean C/D ratio for all patients after engraftment was 1.56-fold higher (p=0.00004, range: 1.04–3.03) than that before engraftment. The variation ratio was calculated by dividing the C/D ratio by that on the engraftment day. Multivariate analysis revealed that the reticulocyte (RET) level (×103 count/µL) was the sole parameter influencing this ratio, and both parameters were expressed as: Variation ratio=0.004×RET+1.0. RET recovery of patients could influence the C/D ratio and tacrolimus clearance was affected by recipient original red blood cells, but not that of transfused red blood cells.
収録刊行物
-
- Biological & Pharmaceutical Bulletin
-
Biological & Pharmaceutical Bulletin 35 (10), 1648-1654, 2012
公益社団法人 日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282679610249856
-
- NII論文ID
- 130001872352
-
- NII書誌ID
- AA10885497
-
- COI
- 1:STN:280:DC%2BC3s%2FisF2gsQ%3D%3D
-
- ISSN
- 13475215
- 09186158
-
- NDL書誌ID
- 023972281
-
- PubMed
- 23037155
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可