Nicotinamide Restores the Reduction of Parvalbumin in Cerebral Ischemic Injury
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- KOH Phil-Ok
- Department of Anatomy, College of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University
書誌事項
- タイトル別名
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- Nicotinamide Attenuates the Decrease of Astrocytic Phosphoprotein PEA-15 in Focal Cerebral Ischemic Injury
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Nicotinamide exerts neuroprotective effects against focal cerebral ischemic injury. Phosphoprotein enriched in astrocytes 15 (PEA-15) is prominently expressed in astrocytes that exert broad anti-apoptotic functions. This study investigated whether nicotinamide modulates PEA-15 and levels of two phosphorylated PEA-15 (Serine 104 and 116) in an animal model of middle cerebral artery occlusion (MCAO)-induced injury. Adult male rats were treated with vehicle or nicotinamide (500 mg/kg) 2 hr after the onset of MCAO and cerebral cortices were collected at 24 hr after MCAO. In a proteomic approach, MCAO induced decreases of PEA-15 levels, while nicotinamide treatment attenuated the injury-induced decrease in PEA-15. The results of Western blot analysis suggest that nicotinamide prevented injury-induced reduction in phospho-PEA-15 (Serine 104) and phospho-PEA-15 (Serine 116) levels. The phosphorylation of PEA-15 exerts anti-apoptotic functions, and reduction of PEA-15 phosphorylation leads to apoptotic cell death. These results suggest that nicotinamide exerts a neuroprotective effect by attenuating the injury-induced decreases of PEA-15 and phospho-PEA-15 (Ser 104 and Ser 116) proteins.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 74 (3), 377-380, 2012
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206428825600
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- NII論文ID
- 130001409977
- 130001879631
- 40019597242
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- NII書誌ID
- AA10796138
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- COI
- 1:STN:280:DC%2BC38znt1KjsA%3D%3D
- 1:STN:280:DC%2BC3s%2FjsFOkug%3D%3D
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- ISSN
- 13477439
- 09167250
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可