Current Perspective : Discriminative Stimulus Effects of Hallucinogenic Drugs : a Possible Relation to Reinforcing and Aversive Effects

• Mori Tomohisa

  Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan

• Yoshizawa Kazumi

  Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan

• Shibasaki Masahiro

  Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan

• Suzuki Tsutomu

  Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan

書誌事項

タイトル別名

• Discriminative Stimulus Effects of Hallucinogenic Drugs: a Possible Relation to Reinforcing and Aversive Effects

抄録

The subjective effects of drugs are related to the kinds of feelings they produce, such as euphoria or dysphoria. One of the methods that can be used to study these effects is the drug discrimination procedure. Many researchers are trying to elucidate the mechanisms that underlie the discriminative stimulus effects of abused drugs (e.g., alcohol, psychostimulants, and opioids). Over the past two decades, the patterns of drug abuse have changed, so that club/recreational drugs such as phencyclidine (PCP), 3,4-methylenedioxymethamphetamine (MDMA), lysergic acid diethylamide (LSD), and ketamine, which induce perceptual distortions, like hallucinations, are now more commonly abused, especially in younger generations. However, the mechanisms of the discriminative stimulus effects of hallucinogenic drugs are not yet fully clear. This review will briefly focus on the recent findings regarding hallucinogenic/psychotomimetic drug–induced discriminative stimulus effects in animals. In summary, recent research has demonstrated that there are at least two plausible mechanisms that can explain the cue of the discriminative stimulus effects of hallucinogenic drugs; one is mediated mainly by 5-HT₂ receptors, and the other is mediated through sigma-1 (σ₁)-receptor chaperone regulated by endogenous hallucinogenic ligand.

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 120 (2), 70-76, 2012

  公益社団法人 日本薬理学会

キーワード

• discriminative stimulus effect
• hallucinogen
• serotonin
• sigma-1 (<I>σ</I><SUB>1</SUB>) receptor

詳細情報

• CRID: 1390282680155811072
• NII論文ID: 10031123548
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.12r08cp
• COI: 1:CAS:528:DC%2BC38Xhs1SrtLfJ
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 024025551
• PubMed: 22986365
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024025551
• Web Site: https://search.jamas.or.jp/link/ui/2013159288
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可