Male Hatano High-Avoidance Rats Show High Avoidance and High Anxiety-Like Behaviors as Compared with Male Low-Avoidance Rats

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  • HORII Yasuyuki
    Department of Basic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University, 1–1 Yanagido, Gifu, Gifu 501-1193, Japan Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, 3–5–8 Saiwaicho, Fuchu, Tokyo 183-8509, Japan
  • KAWAGUCHI Maiko
    School of Agriculture, Meiji University, 1–1–1 Higashimita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan Faculty of Pharmacy and Research Institute of Pharmaceutical Science, Musashino University, 1–1–20 Shinmachi, Nishi-Tokyo, Tokyo 202-8585, Japan
  • OHTA Ryo
    Division of Toxicology, Hatano Research Institute, Food and Drug Safety Center, 729–5 Ochiai, Hadano, Kanagawa 257-8523, Japan
  • HIRANO Akihiro
    School of Agriculture, Meiji University, 1–1–1 Higashimita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan Faculty of Pharmacy and Research Institute of Pharmaceutical Science, Musashino University, 1–1–20 Shinmachi, Nishi-Tokyo, Tokyo 202-8585, Japan
  • WATANABE Gen
    Department of Basic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University, 1–1 Yanagido, Gifu, Gifu 501-1193, Japan Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, 3–5–8 Saiwaicho, Fuchu, Tokyo 183-8509, Japan
  • KATO Nobumasa
    Department of Psychiatry, Showa University School of Medicine, 6–11–11 Kita-Karasuyama, Setagaya-ku, Tokyo 157-8577, Japan JST, CREST
  • HIMI Toshiyuki
    Faculty of Pharmacy and Research Institute of Pharmaceutical Science, Musashino University, 1–1–20 Shinmachi, Nishi-Tokyo, Tokyo 202-8585, Japan
  • TAYA Kazuyoshi
    Department of Basic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University, 1–1 Yanagido, Gifu, Gifu 501-1193, Japan Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, 3–5–8 Saiwaicho, Fuchu, Tokyo 183-8509, Japan

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Our prime objective was to establish an optimal model animal for studying avoidance learning and memory in rodents. The two-way rat inbred strains of Hatano high- (HAA) and low-avoidance (LAA) animals were originally selected and bred in accordance with their high or low performance respectively in the shuttle-box active avoidance task. Previous studies demonstrated that they have clear strain differences in endocrine stress response, which is related to acquisition of aversive learning and emotional reactivity. To evaluate the effect of selection by the shuttle-box task on avoidance performance and emotional reactivity, male Hatano rats underwent passive avoidance, open field and elevated plus maze tests. The present results show that the avoidance performance in the passive task was significantly greater in HAA rats than in LAA rats. Furthermore, HAA rats showed high anxiety-like behaviors compared with LAA rats in open field and elevated plus maze tests. Taken together, this study demonstrated that 1) selection and breeding of Hatano HAA and LAA strain rats by shuttle-box task had been properly carried out with the criterion of high and low avoidance performance respectively and that 2) HAA rats were predisposed to high anxiety compared with LAA rats. These results indicated that Hatano HAA and LAA rats can be useful models for studying avoidance learning and memory.

収録刊行物

  • Experimental Animals

    Experimental Animals 61 (5), 517-524, 2012

    公益社団法人 日本実験動物学会

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