Role of the transcription factor Bcl11b in development and lymphomagenesis

• KOMINAMI Ryo

  Department of Molecular Genetics, Niigata University Graduate School of Medical and Dental Sciences

抄録

Bcl11b is a lineage-specific transcription factor expressed in various cell types and its expression is important for development of T cells, neurons and others. On the other hand, Bcl11b is a haploinsufficient tumor suppressor and loss of a Bcl11b allele provides susceptibility to mouse thymic lymphoma and human T-cell acute lymphoblastic leukemia. Although there are many transcription factors affecting both cell differentiation and cancer development, Bcl11b has several unique properties. This review describes phenotypes given by loss of Bcl11b and roles of Bcl11b in cell proliferation, differentiation and apoptosis, taking tissue development and lymphomagenesis into consideration.<BR><BR>(Communicated by Shigekazu NAGATA, M.J.A.)

収録刊行物

• Ｐｒｏｃｅｅｄｉｎｇｓ　ｏｆ　ｔｈｅ　Ｊａｐａｎ　Ａｃａｄｅｍｙ．　Ｓｅｒ．　Ｂ：　Ｐｈｙｓｉｃａｌ　ａｎｄ　Ｂｉｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ

  Ｐｒｏｃｅｅｄｉｎｇｓ　ｏｆ　ｔｈｅ　Ｊａｐａｎ　Ａｃａｄｅｍｙ．　Ｓｅｒ．　Ｂ：　Ｐｈｙｓｉｃａｌ　ａｎｄ　Ｂｉｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 88 (3), 72-87, 2012

  日本学士院

キーワード

• Bcl11b
• T-cell development
• haploinsufficient tumor suppressor
• T-cell leukemia
• thymic lymphoma

詳細情報

• CRID: 1390001204148020480
• NII論文ID: 130001924739
• NII書誌ID: AA00785485
• DOI: 10.2183/pjab.88.72
• COI: 1:STN:280:DC%2BC38vpslyhtw%3D%3D
• ISSN: 13492896
• ISSN: 03862208
• ISSN: http://id.crossref.org/issn/13492896
• NDL書誌ID: 023513470
• PubMed: 22450536
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023513470
• Web Site: https://www.jstage.jst.go.jp/article/pjab/88/3/88_3_72/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012206814
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可