各種エストロゲン投与による脳下垂体前葉細胞の細胞の組織化学的研究

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  • 木村 肇
    金沢大学医学部産科婦人科学教室大学院

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  • Histochemical Studies on the Effect of Various Estrogenic Compounds upon the Anterior Lobe of the Pituitary Gland
  • 各種エストロゲン投与による脳下垂体前葉細胞の組織化学的研究
  • カクシュ エストロゲン トウヨ ニ ヨル ノウカスイタイ ゼン ヨウ サイボウ ノ ソシキ カガクテキ ケンキュウ

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Uncomfortable side-effects are often observed clinically in the cases of overdosed administration of estrogens as the functions of anterior pituitary were under the influences of estrogen.<BR>The purpose of this article is, therefore, to study histochemical changes of the anterior lobe of the pituitary gland after administration of various kinds of estrogens.<BR>Female, matured and non-parous rats and spayed rats were used as test-animals, and Estradiol benzoate, Estrone, Estrior, Ethinylestradiol, Hexron, Methallenestril and Chlorotrianisene of various con-centration were administered to the animals. Experimented histochemical methods are as follows ; cytol reaction (so called periodic acid-Schiff reaction), pyronin-methylgreen staining, Gomori's aldehyde-fuchsin staining, Gomori's alkaline phosphatase staining, Ohara's method for sulfhydryl and haematoxylin-eosin staining. Changes of weights of the pituitary, adrenal glands and ovaries were also followed.<BR>It could be concluded from the obtained results that : <BR>1) Continuous administration of estrogen of small doses stimulated the anterior pituitary function, while the large doses showed reverse effects.<BR>2) Potency of estrogenic effects could be ranked : Estradiol=Ethinylestradiol>Hexron, Chlorotrianisene>Estrone>Vallestril.<BR>3) Estriol which has been regarded as an estrogen-metabolite showed some mild stimulating effects on the anterior pituitary gland.<BR>4) Notable changes were observed in the basophilic cells of the anterior pituitary gland after the administration of estrogens.<BR>The PAS-positive substance in these cells might have certain relationships with the anterior pituitary function.

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