Comparison of salivary antimicrobial peptides and upper respiratory tract infections in elite marathon runners and sedentary subjects
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- Usui Tatsuya
- Department of Elementary and Preschool Education, Osaka Seikei College
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- Yoshikawa Takahiro
- Department of Sports Medicine, Osaka City University Graduate School of Medicine
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- Orita Keisuke
- Department of Sports Medicine, Osaka City University Graduate School of Medicine
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- Ueda Shin-ya
- Department of Acupuncture, Morinomiya University of Medical Sciences
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- Katsura Yoshihiro
- Department of Health and Physical Education, Kogakuin University
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- Fujimoto Shigeo
- Department of Sports Medicine, Osaka City University Graduate School of Medicine
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The aim of the present study was to examine the relationship between human β-defensin-2 (HBD-2), cathelicidin (LL-37) and upper respiratory tract infections (URTI). In addition, the possible association between salivary cortisol and the salivary antimicrobial peptides was also examined. We hypothesized that the saliva levels of HBD-2 and LL-37 are lower in elite marathon runners; and that saliva cortisol levels might have a negative association with saliva HBD-2 and LL-37. Twenty elite male marathon runners were studied, and twenty additional male subjects were used as sedentary controls. Saliva samples were collected between 12:00 and 14:00 in the afternoon. We selected the cotton swab method of saliva collection. Elite marathon runners tend to have lower concentrations of salivary antimicrobial peptides (HBD-2 and LL-37) than sedentary subjects. Saliva cortisol levels in the elite marathon runners were significantly higher than those in the sedentary subjects. Concentration of saliva cortisol levels showed a negative correlation with saliva HBD-2 and saliva LL-37 concentration levels. Number of URTI in the elite marathon runners was significantly higher than in the sedentary subjects. Number of URTI was negatively correlated with saliva HBD-2 concentration and saliva LL-37 concentration levels. The present findings suggest the relationship between antimicrobial peptides and URTI in elite marathon runners and sedentary subjects. In addition, salivary antimicrobial peptides in the elite marathon runners were significantly lower than sedentary control subjects. It is possible that, while strenuous exercise in elite athletes could partly enhance oral innate immunity, the physical stress could simultaneously restrict the immunological enhancement due to HPA axis activity.
収録刊行物
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- The Journal of Physical Fitness and Sports Medicine
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The Journal of Physical Fitness and Sports Medicine 1 (1), 175-181, 2012
一般社団法人日本体力医学会
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詳細情報 詳細情報について
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- CRID
- 1390001205415939200
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- NII論文ID
- 10031158942
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- NII書誌ID
- AA12573156
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- ISSN
- 21868123
- 21868131
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可