A Molecular Epidemiologic Study of Human Adenovirus Type 8 Isolates Causing Epidemic Keratoconjunctivitis in Kawasaki City, Japan in 2011
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- Fujimoto Tsuguto
- Infectious Disease Surveillance Center, National Institute of Infectious Diseases
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- Matsushima Yuki
- Division of Virology, Kawasaki City Institute of Public Health
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- Shimizu Hideaki
- Division of Virology, Kawasaki City Institute of Public Health
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- Ishimaru Yoko
- Division of Virology, Kawasaki City Institute of Public Health
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- Kano Atsuko
- Division of Virology, Kawasaki City Institute of Public Health
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- Nakajima Etsuko
- Division of Virology, Kawasaki City Institute of Public Health
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- Adhikary Arun Kumar
- Department of Microbiology, BGC Trust Medical College
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- Hanaoka Nozomu
- Infectious Disease Surveillance Center, National Institute of Infectious Diseases
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- Okabe Nobuhiko
- Infectious Disease Surveillance Center, National Institute of Infectious Diseases
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A local outbreak of epidemic keratoconjunctivitis (EKC) caused by human adenovirus type 8 (HAdV-D8) occurred in Kawasaki city, Japan in July–August 2011. Since the cases were sporadic in nature, the source of the infection could not be identified. The results of PCR analysis and the appearance of cytopathic effects in the samples indicated that 22 patients were positive for HAdV. The mean age of the patients (10 men and 12 women) was 64.3 ± 17.3 years (median, 68 years; range, 11–86 years). The sequences of hexon, which included hypervariable loop 1; the penton, which included RGD loops; and the fiber, which included the knob-coding regions, were identical in all the HAdV-positive cases. Phylogenetic analysis of the major capsid protein-encoding regions of HAdV confirmed that the isolates were HAdV-D8. Although the incidence of HAdV-D8 outbreaks has decreased in Japan since 1997, the results of our study imply that HAdV-D8 is still a causative agent for EKC outbreaks in Japan.
収録刊行物
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 65 (3), 260-263, 2012
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390001206240757248
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- NII論文ID
- 130001931816
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- NII書誌ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL書誌ID
- 023661581
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- PubMed
- 22627311
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
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