書誌事項
- タイトル別名
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- Gonadotrophin-Releasing Hormone Agonist in the Treatment of Hypogonadotrophic Secondary Amenorrhoea
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抄録
In an attempt to induce ovulation in Clomiphene resistant secondary amenorrhoea patients, the gonadotrophin-releasing hormone agonist (Buserelin)(600-900μg/day) was administered in 13 cases aged 18 to 24 years for one week from day 5 of the menstrual cycle. Serum levels of luteinizing hormone increased in all patients, and estradiol levels increased in 10 of 13 patients in response to Buserelin. However, ovulation was observed in 6 cases, and the response to Clomiphene was recovered in all of these 6 cases in their subsequent menstrual cycles. These results imply the existence of a subgroup who respond to Buserelin in Clomiphene resistant secondary amenorrhoea patients and a possible new approach for the treatment of secondary amenorrhoea.
収録刊行物
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- Folia Endocrinologica Japonica
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Folia Endocrinologica Japonica 69 (2), 102-108, 1993
The Japan Endocrine Society