アドレナリン作働性薬物およびその遮断剤のラット門脈血中immunoreactive somatostatin (IRS) 濃度におよぼす影響

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  • 戸金 隆三
    東邦大学医学部第一内科
  • 澤野 眞二
    虎の門病院内分泌代謝科;冲中記念成人病研究所;朝日生命成人病研究所
  • 小林 哲郎
    虎の門病院内分泌代謝科;冲中記念成人病研究所;朝日生命成人病研究所
  • 国分 友邦
    工業技術院繊維高分子材料研究所

書誌事項

タイトル別名
  • The Effects of Adrenergic Substances on Portal Immunoreactive Somatostatin (IRS) Levels in Rats
  • アドレナリン サドウセイ ヤクブツ オヨビ ソノ シャダンザイ ノ ラット モ

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The present study was designated to examine the effect of adrenergic agonism on portal IRS levels in rats. Forty-five min after nembutal anesthesia, the rats were infused with 10μg epinephrine (EP), 0.5mg phentolamin (PH), 10μg EP plus 0.5mg PH, 0.3mg Methoxamine (MT), 0.5mg propranolol (PR), 10μg EP plus 0.5mg PR, or 2μg isoproterenol (IS) for 30 min. Two ml physiological saline was infused in a similar way as the control. Immediately before, and 15, 30 and 45 min after initiation of the infusion, portal blood samples were sequentially drawn from the same rats into the test tubes containing EDTA-Trasylol. The concentration of IRS was directly measured by a specific radioimmunoassay using 125I- [Tyr8] -somatostatin as a tracer.<BR>In the saline control group, the preinfusion levels of portal IRS were 249 ± 37pg/ml and slightly but significantly increased to 403 ± 50pg/ml at 30 min (p<0.05). The portal IRS levels at 30 min were increased to 1032 ± 164pg/ml by EP alone, to 1138 ± 240pg/ml by PH alone, and to 1682 ± 238pg/ml by IS alone. These values were significantly higher than each preinfusion level and the value of the saline control group at 30 min. When both EP and PH were administered together, the level by EP alone or by PH alone was raised further as high as 2136 ± 343pg/ml at 30 min. On the other hand, PR alone did not affect portal IRS levels, but PR administered concomitantly with EP completely suppressed the raised level by EP alone to 304 ± 31pg/ml at 30 min (p<0.01). When MT was given, the level of portal IRS at 30 min was 246 ± 32pg/ml. This value was significantly lower than that of the saline control group at 30 min (p<0.05).<BR>These results show that the secretion of IRS to portal blood is stimulated by beta-adrenergic agonism and is inhibited by alpha-adrenergic agonism.

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