Prebiotic Evolution of Oxidoreductases: [Fe(III)(CN)5(L)]<i>n</i>− Complexes as Models

• Kamaluddin

  Department of Chemistry, University of Roorkee

• Nath Mala

  Department of Chemistry, University of Roorkee

• W Deopujari Sushama

  Department of Chemistry, University of Roorkee

抄録

The transition state, where primary ligands like CN− partially replaced by biomolecules, has been assumed to be interesting from point of view of chemical evolution of oxidoreductase enzymes. Complexes of type [Fe(III)(CN)5(L)]n− (where n=2, 3 and L=glycine, imidazole, triglycine, and histidine) are proposed as models for peroxidases and catalases. Detailed kinetic investigations of decomposition of hydrogen peroxide catalyzed by [Fe(III)(CN)5(L)]n− complexes at 40 °C over a wide pH range 6.0–11.0 are discussed. The decomposition reaction is highly pH dependent. In alkaline media, initially L− is substituted by −OH in [Fe(III)(CN)5(L)]; subsequently HOO− binds to −OH through weak intramolecular hydrogen bonding, formation of peroxo complexes has been proposed to be an active intermediate responsible for accelerating the reaction. Decomposition of hydrogen peroxide catalyzed by [Fe(III)(CN)5(L)]n− complexes conforms to Michaelis Menten type of kinetics.

収録刊行物

• Bulletin of the Chemical Society of Japan

  Bulletin of the Chemical Society of Japan 62 (10), 3291-3297, 1989-10-01

  Oxford University Press (OUP)

キーワード

• General Chemistry

詳細情報

• CRID: 1360002219103233280
• NII論文ID: 130001980741
• DOI: 10.1246/bcsj.62.3291
• ISSN: 13480634
• ISSN: 00092673
• Web Site: https://academic.oup.com/bcsj/article-pdf/62/10/3291/55729213/bcsj.62.3291.pdf
• データソース種別:
  • Crossref
  • CiNii Articles