Biomolecules Conform to the Rule of Topological Charge Stabilization

Abstract

<jats:title>Abstract</jats:title> <jats:p>Almost all biomolecules conform to the rule of topological charge stabilization. Heteroatoms are placed at the right sites in proteins, nucleoside bases, porphyrins, and related metabolites. It is noteworthy that typical redox-mediating coenzymes obey this rule both in the oxidized and reduced states. Thus, it is very likely that the rule of topological charge stabilization has been one of the most important guiding principles not only in chemical evolution but also in general biosynthesis.</jats:p>

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