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- Chikara Hongo
- Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd
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- Shigeki Yamada
- Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd
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- Ichiro Chibata
- Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd
抄録
<jats:title>Abstract</jats:title> <jats:p>The asymmetric transformation which converted N-acyl-Dl-amino acids to the desired optically active isomers was studied. N-Acylamino acids such as N-butyrylproline, N-acetylleucine, and N-benzoylphenylglycine were easily racemized in the presence of a catalytic amount of acetic anhydride in melted states or in acetic acid or chloroform solutions. The racemic modification of these N-acylamino acids crystallized as a true racemic mixture suitable for optical resolution by a preferential crystallization procedure under the conditions of racemization. By combining preferential crystallization of the desired enantiomer by seeding from a supercooled melt or a supersaturated solution of a racemic modification and simultaneous racemization of the opposite isomer, N-acyl-Dl-amino acid was partially converted to an optically active isomer and the whole reaction mixture became optically active (10–40% enantiomeric excess).</jats:p>
収録刊行物
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- Bulletin of the Chemical Society of Japan
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Bulletin of the Chemical Society of Japan 54 (11), 3286-3290, 1981-11-01
Oxford University Press (OUP)
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キーワード
詳細情報 詳細情報について
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- CRID
- 1360283694078336768
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- NII論文ID
- 130001987539
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- ISSN
- 13480634
- 00092673
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- データソース種別
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