ヘモグロビン酸素解離曲線におよぼす人工炭酸泉浴の効果

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  • Effect of artificial carbon dioxide bathing on oxygen-dissociation curve of hemoglobin.
  • ヘモグロビン サンソ カイリ キョクセン ニ オヨボス ジンコウ タンサンセン

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Many researchers have pointed out that CO2 bathing directly effects expanding dermal vessels. The authors have recently reported a decrease in red blood cell after CO2 bathing. To clarify other effects of CO2 bathing on RBC, the changes in the hemoglobinoxygen-dissociation curve (P50) were measured after single bathing (for 10 minutes at 40°C) with artificial CO2 water made of sodium bicarbonate and citric acid dissolved in plain water. P50 was measured with an oxygen-dissociation analyzer (HEMO-O-SCANTM made by American Instrument Company) and 2, 3-diphosphoglycerate (2, 3-DPG) in RBC, with enzymatic analysis. The subjects of this study consisted of six male patients and four female patients, ranging from 53 to 80 years old.<br>The results are presented below.<br>1) Nine of ten patients showed an increase in P50 after 15 to 30 minutes of CO2 bathing. The remainder showed a transient increase in P50.<br>2) No significant increase in 2, 3-DPG concentration in RBC was found in the group subjected to CO2 bathing as compared to that of the controls who were subjected to plain water bathing. However, seven patients showed an increase in 2, 3-DPG after 15 to 30 minutes of CO2 bathing, and three patients showed a decrease in 2, 3-DPG.<br>3) Partial pressures of oxygen (PO2) and carbon dioxide (PCO2) in the venous blood were measured. Elevation of PO2, lowering of PCO2, and increase in pH were observed in almost all patients after a single CO2 bath.<br>From these results, we can conclude that a single CO2 bath effectively decreases oxygen affinity of hemoglobin, presumably due to a rise in the blood temperature and partially due to an increase in 2, 3-DPG concentration in RBC.

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