Ｔｒａｘａｎｏｘ　Ｓｏｄｉｕｍの健常人における利尿作用および尿酸排せつ作用　　反復投与試験によるＨｙｄｒｏｃｈｌｏｒｏｔｈｉａｚｉｄｅとの比較

DOI

書誌事項

タイトル別名
  • Diuretic and uricosuric effects of traxanox sodium in healthy subjects: Comparison with hydrochlorothiazide by multiple-dose study.
  • 反復投与試験によるHydrochlorothiazideとの比較

抄録

Diuretic and uricosuric effects of traxanox sodium (TRX, 180 mg three times daily for 8 days) were investigated by double blind, cross over comparison with hydro chlorothiazide (HCT, 25 mg twice daily for 8 days).<BR>Urine volume and urinary excretion of electrolytes increased after the administration of TRX. Asimilar trend was observed on HCT. The urinary excretion of uric acid increased and serum concentration of uric acid decreased on TRX. However, the urinary excreti on of uric acid decreased and serum concentration of uric acid in creased on HCT.<BR>Serum Na, K and Cl decreased, while serum Ca and PRA increased on HCT, while only serum Cl decreased on TRX. Neither drug induced any significant changes in blood pressure, pulse rate, body temperature or body weight.<BR>These results show that TRX has a uricosuric effect in humans.

収録刊行物

  • 臨床薬理

    臨床薬理 18 (4), 619-626, 1987

    一般社団法人 日本臨床薬理学会

キーワード

詳細情報 詳細情報について

  • CRID
    1390001205369057280
  • NII論文ID
    130002046947
  • DOI
    10.3999/jscpt.18.619
  • ISSN
    18828272
    03881601
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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