塩酸Dilazepのヘモグロビン酸素解離曲線に及ぼす影響 In VitroおよびIn Vivoにおける研究
書誌事項
- タイトル別名
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- Effects of Dilazep Dihydrochloride on the Oxygen Dissociation Curve of the Hemoglobin
- In VitroおよびIn Vivoにおける研究
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The present study was undertaken to estimate in vitro and in vivo effects of dilazep on the hemoglobin-oxygen dissociation curve of venous blood from 16 healthy men.<BR>Dilazep (5×10-6 to 5×10-4M) significantly shifted the oxygen dissociation curve of the hemoglobin to the right but did not affect the 2, 3-DPG contents on incubation of blood samples for 2 to 4 hours with the drug. In vivo administration of dilazep (300mg/day for one week), however, produced a significant shift of the curve to the left. This leftward shift was accompanied with a tendency for contents of 2, 3-DPG to decrease without a significant changes in HbAIC levels. There were no changes observed in P50, 2, 3-DPG and HbAlc levels with a lower dosage of dilazep (150 mg/day for oneweek).<BR>These findings suggested that the increased oxygen binding to hemoglobin induced by dilazep in vivo resulted from a probable increase in systemic oxygen delivery due to its vasodilating effects.
収録刊行物
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- 臨床薬理
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臨床薬理 14 (2), 357-363, 1983
一般社団法人 日本臨床薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205367688704
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- NII論文ID
- 130002047757
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- ISSN
- 18828272
- 03881601
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可