A Comparison of Langerhans Cell Numbers in Tobacco-associated Leukoplakia and Oral Squamous Cell Carcinoma

• Narwal Anjali

  Department of Oral Pathology, Govt Dental College

• Saxena Susmita

  Department of Oral Pathology, Subharti Dental College

抄録

Objective : Langerhans cells form a network of immune competent cells in the epithelium of oral mucosa and alterations in their number on exposure to tobacco might impair mucosal immunologic protection against mutagens and can have a role in epithelial dysplasia and carcinoma.<br>Study design : Study was divided into 4 groups : formalin fixed paraffin embedded tissues from group A without tobacco habit (normal mucosa), and other groups with tobacco habits, B (leukoplakia without dysplasia), C (leukoplakia with dysplasia) and D (Squamous cell carcinoma). LCs were detected by using immunohistochemical marker CD1a and cells were counted in the epithelium using ImagePro software.<br>Results : Comparision of mean LC count among study groups showed lesser number of LCs as compared to the normal mucosa. In carcinoma sections, LCs were least in number as compared to other groups. Quantitative analysis using Tukey test showed significant difference in LC count among study groups whereas Unpaired “t” test revealed non significant comparision of mean LC count between smokers and chewers.<br>Conclusion : Tobacco either in the form of smoking or chewing affects the peripheral immune arbiters of oral mucosa i.e. LCs.

収録刊行物

• ＩＪＯＭＳ

  ＩＪＯＭＳ 10 (3), 125-131, 2011

  日本大学松戸歯学部 口腔科学研究所

キーワード

• squamous cell carcinoma
• dysplasia
• leukoplakia

詳細情報

• CRID: 1390001205212580224
• NII論文ID: 130002051642
• DOI: 10.5466/ijoms.10.125
• ISSN: 21854254
• ISSN: 13479733
• Web Site: http://www.jstage.jst.go.jp/article/ijoms/10/3/10_3_125/_pdf
• 本文言語コード: en
• データソース種別:
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