Immunoglobulin-associated Creatine Kinase Masquerading as Macro-creatine Kinase Type 2 in a Statin User
-
- Loh Tze Ping
- Department of Laboratory Medicine, National University Hospital, Singapore
-
- Ang Yan Hoon
- Department of Geriatric Medicine, Khoo Teck Puat Hospital, Singapore
-
- Neo Siew Fong
- Department of Laboratory Medicine, National University Hospital, Singapore
-
- Yin Cecilia
- Department of Laboratory Medicine, National University Hospital, Singapore
-
- Wong Moh Sim
- Department of Laboratory Medicine, Khoo Teck Puat Hospital, Singapore
-
- Leong Sai Mun
- Department of Laboratory Medicine, National University Hospital, Singapore Department of Pathology, National University of Singapore, Singapore
-
- Saw Sharon
- Department of Laboratory Medicine, National University Hospital, Singapore
-
- Sethi Sunil K.
- Department of Laboratory Medicine, National University Hospital, Singapore Department of Pathology, National University of Singapore, Singapore
この論文をさがす
抄録
Macro-creatine kinase (CK) is a cause of falsely elevated CK. Macro-CK type 1 is immunoglobulin-associated CK; type 2 is polymeric mitochondrial-CK. An elderly asymptomatic lady had an elevated CK level after receiving statin therapy. Her CK gel electrophoresis analysis demonstrated coexisting macro-CK type 1 and type 2 patterns. Further analysis by immunofixation and mixing this patient's serum with CK control material revealed an IgG-associated macro-CK that mimicked the electrophoretic pattern of macro-CK type 2. This highly unusual discovery suggests the possibility of the misinterpretation of macro-CK type 1 as macro-CK type 2. Falsely elevated CK is still common despite modern laboratory instrumentation and should be investigated.<br>
収録刊行物
-
- Internal Medicine
-
Internal Medicine 51 (9), 1061-1064, 2012
一般社団法人 日本内科学会