Pulmonary Tumor Thrombotic Microangiopathy Diagnosed Antemortem and Treated with Combination Chemotherapy
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- Kayatani Hiroe
- Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan
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- Matsuo Kiyoshi
- Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan
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- Ueda Yusuke
- Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan
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- Matsushita Mizuho
- Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan
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- Fujiwara Keiichi
- Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan
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- Yonei Toshiro
- Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan
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- Yamadori Ichiro
- Department of Clinical Pathology, National Hospital Organization Okayama Medical Center, Japan
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- Shigematsu Hisayuki
- Department of Chest Surgery, National Hospital Organization Okayama Medical Center, Japan
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- Andou Akio
- Department of Chest Surgery, National Hospital Organization Okayama Medical Center, Japan
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- Sato Toshio
- Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan
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抄録
A 29-year-old man developed a persistent dry cough. Chest high-resolution computed tomography (HRCT) revealed centrilobular ultrafine granular shadows scattered in all lung fields. A lung biopsy with video-assisted thoracoscopic surgery revealed findings compatible with pulmonary tumor thrombotic microangiopathy (PTTM). However, the primary tumor was not identified. Combination chemotherapy with S-1 and cisplatin decreased his cough and improved the chest HRCT findings. The illness, however, gradually became difficult to control. He eventually developed pulmonary hypertension and died. Typically, an antemortem diagnosis of PTTM cannot be made. In this case, the diagnosis of PTTM and combination chemotherapy improved the chest HRCT findings, respiratory symptoms, and prognosis.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 51 (19), 2767-2770, 2012
一般社団法人 日本内科学会
