Immunopathological Analysis of Erdheim-Chester Disease with Massive Ascites

  • Ota Muneo
    Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan
  • Sakamoto Mayuko
    Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan
  • Sato Kojiro
    Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan
  • Yoshida Yoshihiro
    Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan
  • Funakubo Asanuma Yu
    Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan
  • Akiyama Yuji
    Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan
  • Yamakawa Mitsunori
    Department of Pathological Diagnostics, Faculty of Medicine, Yamagata University, Japan
  • Mimura Toshihide
    Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan

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抄録

We treated a 77-year-old woman with pleural and pericardial effusion and ascites. Initially, collagen vascular disease was suspected due to the presence of anti-centromere antibodies and suspected complication of pulmonary arterial hypertension. However, soft-tissue abnormalities surrounding the bilateral kidneys detected on computed tomography (CT) and symmetrical lesions of the long bones detected on bone scintigraphy made us consider a diagnosis of Erdheim-Chester disease (ECD), which is a rare form of histiocytosis. We immunochemically analyzed the cells derived from the ascites in detail and confirmed the diagnosis. Immunocytochemical analyses may therefore help to achieve a better understanding of the pathogenesis of this rare disease.<br>

収録刊行物

  • Internal Medicine

    Internal Medicine 51 (19), 2825-2830, 2012

    一般社団法人 日本内科学会

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