Diffuse Tubulointerstitial Nephritis Accompanied by Renal Crystal Formation in an HIV-infected Patient Undergoing Highly Active Antiretroviral Therapy

  • Kanzaki Go
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Japan
  • Tsuboi Nobuo
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Japan
  • Miyazaki Yoichi
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Japan
  • Yokoo Takashi
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Japan
  • Utsunomiya Yasunori
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Japan
  • Hosoya Tatsuo
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Japan

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抄録

This report presents a human immunodeficiency virus (HIV) patient that developed a slowly progressive renal impairment over years under highly active antiretroviral therapy (HAART). The renal biopsy showed diffuse tubulointerstitial nephritis accompanied by crystal formations that were surrounded by multinuclear giant cells. Furthermore, rod-like crystals were detected in the urinary sediments. Tenofovir and Atazanavir were thought to be the causative drugs for the renal injury. Therefore, the possibility of HARRT-induced nephrotoxicity should be considered in HIV-infected patients, even though the activity of HIV is controlled by such therapies.<br>

収録刊行物

  • Internal Medicine

    Internal Medicine 51 (12), 1543-1548, 2012

    一般社団法人 日本内科学会

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