Sub-acute Demyelinating Polyradiculoneuropathy as an Initial Symptom of Peripheral T Cell Lymphoma, Not Otherwise Specified (PTCL-NOS)
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- Kawanishi Kazunobu
- Division of Hematology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kinki University, Japan
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- Ohyama Yasuyo
- Division of Hematology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kinki University, Japan
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- Kanai Yoshitake
- Division of Hematology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kinki University, Japan
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- Hirase Tikara
- Division of Hematology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kinki University, Japan
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- Tanaka Hirokazu
- Division of Hematology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kinki University, Japan
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- Miyatake Junichi
- Division of Hematology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kinki University, Japan
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- Tatsumi Youichi
- Division of Hematology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kinki University, Japan
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- Ashida Takashi
- Division of Hematology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kinki University, Japan
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- Nakamine Hirokazu
- Pathology and Immunology Division, Kansai University for Health Sciences, Japan
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- Matsumura Itaru
- Division of Hematology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kinki University, Japan
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抄録
Here we report the first case of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), who initially presented with peripheral neuropathy. Nerve conduction, cerebral spinal fluid studies and his clinical course were compatible with sub-acute demyelinating polyradiculoneuropathy. In addition, left cervical lymph node swelling was observed on admission. Diagnosis of PTCL-NOS was made by the histological, immunohistochemical, and Southern blot analyses on the biopsy specimen from the enlarged lymph node. Combination chemotherapy composed of cyclophosphamide, vincristine, doxorubicin and prednisolone (CHOP) was effective for polyneuropathy as well as for lymphoma. Several antibodies relating to paraneoplastic syndrome such as Ma1, Ma2, Amphiphysin, CV2, Ri, Yo and Hu were all negative. Because sural nerve biopsy performed prior to CHOP therapy revealed no infiltration of lymphoma cells, immune dysfunction mediated by some cytokine or unidentified autoantibody related to PTCL-NOS was thought to be involved in the polyradiculoneuropathy.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 51 (15), 2015-2020, 2012
一般社団法人 日本内科学会