Partial Improvement of Anterior Pituitary Deficiency Following Steroid Treatment in a Patient with Neurosarcoidosis Accompanied by Central Diabetes Insipidus
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- Tanaka Ken-ichiro
- Internal Medicine I, Shimane University Faculty of Medicine, Japan
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- Yamamoto Masahiro
- Internal Medicine I, Shimane University Faculty of Medicine, Japan
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- Okazaki Kyoko
- Internal Medicine I, Shimane University Faculty of Medicine, Japan
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- Yamaguchi Toru
- Internal Medicine I, Shimane University Faculty of Medicine, Japan
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- Sugimoto Toshitsugu
- Internal Medicine I, Shimane University Faculty of Medicine, Japan
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抄録
A 58-year-old woman was admitted due to visual field abnormalities, thirst, polydipsia, polyuria and fever. T1-weighted magnetic resonance imaging revealed an absence of the usual bright signal in the posterior lobe of the pituitary gland, and an enlarged pituitary gland with a thickened stalk was enhanced by the gadolinium contrast medium. Computed tomography revealed tumor lesions in the left maxillary sinus and right retroperitoneum and axillary and subclavian lymph node swelling. An endocrinological provocation test demonstrated that her pituitary endocrine function was disturbed, although her ACTH and TSH secretion was normal. The patient was histologically diagnosed with neurosarcoidosis accompanied by hypopituitarism and central diabetes insipidus upon an examination of a subclavian lymph node specimen. Six months of prednisolone treatment resulted in the disappearance of any morphological abnormalities in the pituitary gland and stalk as well as a partial improvement in her LH, FSH and GH secretions. Pituitary endocrine functions can be rescued if steroid treatment is performed under conditions that maintain several hormonal axes.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 51 (16), 2175-2179, 2012
一般社団法人 日本内科学会