Etanercept-Induced Lupus Accompanied by Hemophagocytic Syndrome

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  • Araki Daisuke
    Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Japan
  • Fujii Hiroshi
    Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Japan
  • Matsumura Masami
    Research Center for Medical Education, Kanazawa University Graduate School of Medicine, Japan
  • Yamagishi Masakazu
    Division of Cardiology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Japan
  • Yachie Akihiro
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan
  • Kawano Mitsuhiro
    Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Japan

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Hemophagocytic syndrome (HPS) is a severe, potentially life-threatening disorder characterized by an excessive activation of macrophages, such as may occur in the setting of lupus. A 62-year-old Japanese woman treated with etanercept for rheumatoid arthritis developed persistent fever, cytopenia, coagulopathy, and hyperferritinemia. Simultaneously, lupus-like features including pleuritis, hypocomplementemia, and positive autoantibodies were observed. She was diagnosed with HPS related to etanercept-induced lupus, and underwent immunosuppressive therapy with successful recovery. To our knowledge, this is the first case of etanercept-induced lupus accompanied by HPS. This case suggests that HPS should be considered as a complication during TNF-α inhibitor therapy.<br>

収録刊行物

  • Internal Medicine

    Internal Medicine 50 (17), 1843-1848, 2011

    一般社団法人 日本内科学会

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