Internal Medicine : Trapped Neutrophil Syndrome in a Border Collie Dog : Clinical, Clinico-Pathologic, and Molecular Findings

DOI Web Site Web Site PubMed 参考文献7件
  • MIZUKAMI Keijiro
    Laboratory of Clinical Pathology, Department of Veterinary Medicine, Kagoshima University, 1-21-24 Kohrimoto, Kagoshima 890-0065, Japan
  • SHOUBUDANI Tomoaki
    Athena Pet Care Clinic, 3 Tamaike-cho, Nishi-ku, Nagoya 452-0812, Japan
  • NISHIMOTO Seira
    Athena Pet Care Clinic, 3 Tamaike-cho, Nishi-ku, Nagoya 452-0812, Japan
  • KAWAMURA Ryuta
    Athena Pet Care Clinic, 3 Tamaike-cho, Nishi-ku, Nagoya 452-0812, Japan
  • YABUKI Akira
    Laboratory of Clinical Pathology, Department of Veterinary Medicine, Kagoshima University, 1-21-24 Kohrimoto, Kagoshima 890-0065, Japan
  • YAMATO Osamu
    Laboratory of Clinical Pathology, Department of Veterinary Medicine, Kagoshima University, 1-21-24 Kohrimoto, Kagoshima 890-0065, Japan

書誌事項

タイトル別名
  • Trapped Neutrophil Syndrome in a Border Collie Dog: Clinical, Clinico-Pathologic, and Molecular Findings

この論文をさがす

抄録

Trapped neutrophil syndrome (TNS) is an autosomal recessive inherited neutropenia known in Border Collies since the 1990’s. Recently, the causative mutation has been identified in the canine VPS13B gene and a DNA-based diagnosis has now become available. The present paper describes clinical and clinico-pathologic findings in a Border Collie with TNS that was molecularly diagnosed for the first time in Japan. In a 10-week-old male Border Collie with microgenesis and symptoms related to recurrent infections, a hematological examination revealed severe leukopenia due to neutropenia, suggesting the dog to be affected by inherited neutropenic immunodeficiency. Direct DNA sequencing demonstrated that the dog was homozygous for the causative mutation of TNS and both its parents were heterozygous carriers. In addition, a simple and rapid polymerase chain reaction-based length polymorphism analysis coupled with microchip electrophoresis was developed for the genotyping of TNS. This assay could discriminate clearly all genotypes, suggesting that it was suitable for both individual diagnosis and large-scale surveys for prevention.

収録刊行物

参考文献 (7)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ