Effect of Dietary Porphyran from the Red Alga, Porphyra yezoensis, on Glucose Metabolism in Diabetic KK-Ay Mice
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- KITANO Yuki
- Graduate School of Agriculture, Kyoto University
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- MURAZUMI Koki
- Graduate School of Agriculture, Kyoto University
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- DUAN Jingjing
- Graduate School of Agriculture, Kyoto University
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- KUROSE Kosuke
- Research and Development Center, Shirako Co., Ltd.
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- KOBAYASHI Shunichi
- Research and Development Center, Shirako Co., Ltd.
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- SUGAWARA Tatsuya
- Graduate School of Agriculture, Kyoto University
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- HIRATA Takashi
- Graduate School of Agriculture, Kyoto University
書誌事項
- タイトル別名
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- Effect of Dietary Porphyran from the Red Alga, <i>Porphyra yezoensis</i>, on Glucose Metabolism in Diabetic KK-Ay Mice
- Effect of dietary porphyrin from the red alga, Porphyra yezoensis, on glucose metabolism in diabetic KK-Ay mice
この論文をさがす
抄録
Porphyran (POR) from the red alga Porphyra yezoensis is a water soluble dietary fiber. In this study, we investigated the effect of dietary POR on glucose metabolism in KK-Ay mice (a model for type 2 diabetes). Mice were divided into 4 groups and fed a diet containing 5% cellulose (control), POR, POR Arg or POR K. After 3 wk of feeding, plasma insulin levels and the calculated homeostasis model assessment-insulin resistance (HOMA-IR) index were significantly lower in the POR group than in the control group. Compared with the control group, plasma adiponectin levels were significantly increased in the POR, POR Arg and POR K groups. These results suggest that dietary POR should improve glucose metabolism in diabetes via up-regulation of adiponectin levels. In addition, the amount of propionic acid in the cecum of the POR group was significantly higher than in the control group and the profile of bacterial flora was changed by dietary POR. In the cecum of the POR, POR Arg and POR K groups, Bacteroides was significantly increased and Clostridium coccoides was significantly decreased compared with in the control group. The effects of dietary POR on the hindgut environment might contribute to the improvement of glucose metabolism.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 58 (1), 14-19, 2012
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詳細情報 詳細情報について
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- CRID
- 1390282681303160576
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- NII論文ID
- 130002103058
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- NII書誌ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BC38Xjs1Klu7s%3D
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- ISSN
- 18817742
- 03014800
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- HANDLE
- 2433/166070
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- NDL書誌ID
- 023457460
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- PubMed
- 23007062
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可