耳鳴症例に対するメラトニン受容体アゴニスト（ラメルテオン）の効果

• 荒尾 はるみ

  荒尾内科・耳鼻咽喉科（稲沢市）

書誌事項

タイトル別名

• Effect of Ramelteon (Agonist of Melatonin) on Tinnitus
• 薬物 耳鳴症例に対するメラトニン受容体アゴニスト(ラメルテオン)の効果
• ヤクブツ ミミナリ ショウレイ ニ タイスル メラトニン ジュヨウタイ アゴニスト(ラメルテオン)ノ コウカ

抄録

Ramelteon is a melatonin receptor agonist. Melatonin, a neurohormone secreted by the pineal gland at night, helps regulate the sleep-wake cycle, although tinnitus disturbs sleep. To evaluate ramelteon in treating subjective tinnitus, we administered it internally to 42 subjects not sufficient effectively aided by usual internal treatment. Subjects took 8.0 mg of ramelteon, nightly for 2 weeks or more. We evaluated results, using a visual analog scale (VAS) of the standardized, 1993 Tinnitus Study Group tinnitus test, the tinnitus handicap inventory (THI) for 25 subjects and symptom changes in all 42 subjects. Of the 42 (88.1%), 37 could take ramelteon. Of these 37 (64.9%), 24 improved subjectively, after taking ramelteon.<br> In 7 subjects with Meniere’s disease (MD), 6 improved, possibly from MD melatonin deficiency¹²⁾. Mean VAS and THI decreased significantly between weeks 0 and 4-16 in Wilcoxon’s signed rank test, after taking ramelteon.<br> Ramelteon thus appears to be useful in treating subjective tinnitus, and subjects with MD are most likely to benefit from ramelteon treatment.<br>

収録刊行物

• 耳鼻咽喉科臨床

  耳鼻咽喉科臨床 105 (2), 167-176, 2012

  耳鼻咽喉科臨床学会

キーワード

• ramelteon
• tinnitus
• melatonin receptor agonist
• Meniere’s disease

詳細情報

• CRID: 1390001204271939840
• NII論文ID: 10030176444
• NII書誌ID: AN00107089
• DOI: 10.5631/jibirin.105.167
• ISSN: 18844545
• ISSN: 00326313
• NDL書誌ID: 023511335
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023511335
• Web Site: https://search.jamas.or.jp/link/ui/2012172557
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可