A CHALLENGE TO APPROPRIATE ANTIBIOTIC USE IN CHILDREN WITH RESPIRATORY INFECTIONS: A 5-YEAR SINGLE-INSTITUTION EXPERIENCE
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- MATSUMOTO AYUMI
- Department of Pediatrics, Fukushima Medical University
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- HASHIMOTO KOICHI
- Department of Pediatrics, Fukushima Medical University
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- KAWASAKI YUKIHIKO
- Department of Pediatrics, Fukushima Medical University
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- HOSOYA MITSUAKI
- Department of Pediatrics, Fukushima Medical University
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Background<br>We have studied the rate of emergence of anitibiotic-resistant Streptococcus pneumoniae (S. pneumoniae) and Haemophilus influenzae (H. influenzae) and the subsequent antibiotic use in host patients of those isolates at the Department of Pediatrics, Soma General Hospital, Fukushima. Moreover, we carried out several studies investigating the risks and benefits of antibiotic-free treatment for children with respiratory infections. In this report, we summarize our research and suggest better treatment options for pediatric patients with respiratory infections. <br>Methods<br>We investigated the necessity of antibiotic use in the treatment of pediatric inpatients with respiratory syncytial virus (RSV) infection, and tested our hypothesis that antibiotic-free treatment for common cold will reduce the number of resistant S. pneumoniae strains in the pediatric nasopharynx. Therefore, we restricted prescribing antibiotics for pediatric patients with respiratory infections. The rates of resistant S. pneumoniae and H. influenzae and the medication history of the host patients before and after the intervention were compared. <br>Results<br>We found that most of the RSV-infected patients recovered without antibiotic treatment, and that the antibiotic-free treatment inhibited the emergence of antibiotic-resistant strains. The rate of penicillin-resistant S. pneumoniae decreased but the rate of ampicillin-resistant H. influenzae did not change significantly during the study. <br>Conclusion<br>We concluded that patients with respiratory infections can be treated without antibiotics, under careful examination and observation. Continued monitoring of such new interventions as well as recommending their use to other caregivers and physicians will help inhibit the spread of resistant strains.
収録刊行物
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- 福島医学会
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福島医学会 57 (2), 33-45, 2011
福島医学会
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詳細情報 詳細情報について
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- CRID
- 1390282681282848640
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- NII論文ID
- 130002153580
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- NII書誌ID
- AA0065246X
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- COI
- 1:STN:280:DC%2BC383lt1yqtw%3D%3D
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- ISSN
- 21854610
- 00162590
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
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- CiNii Articles
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- 使用不可