Paliperidoneを含有する浸透圧ポンプを利用した放出制御錠剤のReciprocating Cylinder法による溶出特性の評価
書誌事項
- タイトル別名
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- Evaluation of Dissolution of Osmotic-Controlled Release Paliperidone Tablets Using the Reciprocating Cylinder Method
- Paliperidone オ ガンユウ スル シントウアツ ポンプ オ リヨウ シタ ホウシュツ セイギョ ジョウザイ ノ Reciprocating Cylinderホウ ニ ヨル ヨウシュツトクセイ ノ ヒョウカ
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抄録
The dissolution profiles of paliperidone from INVEGA® 3-mg tablets, osmotic-controlled release tablets, were evaluated by using the reciprocating cylinder method (RC method). We used 4 different compositions of the dissolution fluids, by considering the environment of the tablet in the gastrointestinal tract. After a lag time of 2 to 4 h, paliperidone was approximately dissolved to 24 h by zero-order release. The dissolution characteristics of paliperidone were not affected by the kind of the test medium, pH, and surfactant. In addition, the dissolution of the tablets was evaluated using the paddle method in distilled water, Japanese Pharmacopeia (JP) 1st test fluid, and JP 2nd test fluid. The dissolution profiles of paliperidone obtained using the RC method and the paddle method were very similar. Further, the dispersion of the percentage of the dissolved paliperidone obtained using the RC method and the paddle method was small.<br>
収録刊行物
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- 薬学雑誌
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薬学雑誌 133 (3), 405-410, 2013-03-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282681105455360
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- NII論文ID
- 40019600971
- 130002489280
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- NII書誌ID
- AN00284903
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- COI
- 1:STN:280:DC%2BC3s3js1Kqtw%3D%3D
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 024312123
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- PubMed
- 23257415
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可