Designing Caged Compounds for Spatiotemporal Control of Cellular Chemistry

• Furuta Toshiaki

  Department of Biomolecular Science, Faculty of Science, Toho University

抄録

Photoirradiation of an appropriately designed caged compound enables the control and manipulation of biological processes in living cells with high spatial and temporal resolution. Brominated (coumarin-4-yl)methyl groups were designed to have favorable photochemical and physical properties as photoremovable protecting groups of caged compounds. Caged compounds of various types of biologically related molecules including neurotransmitters, second messengers, inhibitors of some proteins and mRNAs have been synthesized. A membrane-permeable caged cGMP, Bhc-cGMP/Ac, controlled a cGMP-dependent signaling pathway in a freely swimming sperm cell. Spot illumination of Bhcmoc-diC8 produced localized accumulation of diacylglycerol in a single T-cell.

収録刊行物

• 有機合成化学協会誌

  有機合成化学協会誌 70 (11), 1164-1169, 2012

  公益社団法人 有機合成化学協会

キーワード

• Organic Chemistry

詳細情報

• CRID: 1390282680316016896
• NII論文ID: 10031131195
• NII書誌ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.70.1164
• COI: 1:CAS:528:DC%2BC38XhslCjsrvE
• ISSN: 18836526
• ISSN: 00379980
• NDL書誌ID: 024087911
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024087911
• 本文言語コード: en
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• 抄録ライセンスフラグ: 使用不可