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- Nakamura Masaru
- Department of Psychiatric Internal Medicine, Kosekai-Kusatsu Hospital
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- Satoh Yumi
- Department of Internal Medicine, Kosekai-Kusatsu Hospital
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- Hiraoka Akito
- Department of Internal Medicine, Kosekai-Kusatsu Hospital
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- Fujita Yasutaka
- Department of Psychiatry, Kosekai-Kusatsu Hospital
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- Nagamine Takahiko
- Department of Psychiatric Internal Medicine, Seiwakai-Kitsunan Hospital
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Hyponatremia and syndrome of inappropriate secretion of antidiuretic hormone (SIADH) are recognized as serious side effects of selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs). As elderly patients are easily predisposed to hyponatremia due to multiple factors, the use of SSRIs or SNRIs may be more likely to aggravate hyponatremia. We report the case of an elderly patient who developed hyponatremia most likely related to SIADH induced by duloxetine, an SNRI. Symptoms of hyponatremia emerged after treatment initiation and resolved with conservative care following discontinuation of duloxetine. Severe hyponatremia, serum hypoosmolality, urine osmolality, and measurable levels of plasma antidiuretic hormone suggested SIADH. Multiple factors, such as physical comorbidities and conditions, and drug interactions, might be associated with hyponatremia. Older patients receiving SNRIs or SSRIs should be closely monitored for clinical and laboratory evidence of hyponatremia.
収録刊行物
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- Clinical Neuropsychopharmacology and Therapeutics
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Clinical Neuropsychopharmacology and Therapeutics 3 (0), 33-36, 2012
日本臨床精神神経薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282680313334016
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- NII論文ID
- 130003303683
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- ISSN
- 18848826
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可