The Clinical Characteristics of Two Anti-OJ (Anti-Isoleucyl-tRNA Synthetase) Autoantibody-Positive Interstitial Lung Disease Patients with Polymyositis/Dermatomyositis
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- Kunimasa Kei
- Department of Respiratory Medicine, Kurashiki Central Hospital, Japan Division of Genetics, Kobe University Graduate School of Medicine, Japan
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- Arita Machiko
- Department of Respiratory Medicine, Kurashiki Central Hospital, Japan
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- Nakazawa Takashi
- Department of Endocrinology and Rheumatology, Kurashiki Central Hospital, Japan
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- Tanaka Maki
- Department of Respiratory Medicine, Kurashiki Central Hospital, Japan
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- Tsubouchi Kazuya
- Department of Respiratory Medicine, Kurashiki Central Hospital, Japan Department of Respiratory Medicine, St. Mary's Hospital, Japan
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- Konishi Satoshi
- Department of Respiratory Medicine, Kurashiki Central Hospital, Japan Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan
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- Fukuda Yasushi
- Department of Respiratory Medicine, Kurashiki Central Hospital, Japan
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- Saigusa Mika
- Department of Respiratory Medicine, Kurashiki Central Hospital, Japan Department of Palliative Medicine, Okayama Saiseikai General Hospital, Japan
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- Nakagawa Hiroaki
- Department of Respiratory Medicine, Kurashiki Central Hospital, Japan Department of Respiratory Medicine, Shiga University of Medical Science, Japan
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- Ubukata Satoshi
- Department of Respiratory Medicine, Kurashiki Central Hospital, Japan Department of Respiratory Diseases, Saka General Hospital, Japan
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- Korogi Yohei
- Department of Respiratory Medicine, Kurashiki Central Hospital, Japan
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- Fujii Takao
- Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Japan
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- Mimori Tsuneyo
- Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Japan
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- Ishida Tadashi
- Department of Respiratory Medicine, Kurashiki Central Hospital, Japan
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抄録
We herein report the clinical and laboratory characteristics of two anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibody-positive interstitial lung disease patients with polymyositis/dermatomyositis (PM/DM). We compared these characteristics with previously published findings. Previous reports and our present cases show that anti-OJ autoantibody-positive interstitial lung disease (ILD) patients with PM/DM lack the manifestations of Raynaud's phenomenon and sclerodactyly and show good prognoses and responses to glucocorticoid therapy. These results indicate that the presence of anti-OJ autoantibodies may be useful for predicting the prognosis of ILD and its clinical course in PM/DM patients.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 51 (24), 3405-3410, 2012
一般社団法人 日本内科学会